Hi smile,

Refer below code.

C#

protected void btnGenerate_Click(object sender, EventArgs e)
{
    string code = txtCode.Text;
    QRCodeGenerator qrGenerator = new QRCodeGenerator();
    QRCodeGenerator.QRCode qrCode = qrGenerator.CreateQrCode(code, QRCodeGenerator.ECCLevel.Q);
    System.Web.UI.WebControls.Image imgBarCode = new System.Web.UI.WebControls.Image();
    imgBarCode.Height = 150;
    imgBarCode.Width = 150;
    using (Bitmap bitMap = qrCode.GetGraphic(20))
    {
        using (MemoryStream ms = new MemoryStream())
        {
            bitMap.Save(ms, System.Drawing.Imaging.ImageFormat.Png);
            byte[] byteImage = ms.ToArray();
            imgBarCode.ImageUrl = "data:image/png;base64," + Convert.ToBase64String(byteImage);
            plBarCode.Controls.Add(imgBarCode);

            // Saving QRCode to database.
            string constr = ConfigurationManager.ConnectionStrings["constr"].ConnectionString;
            using (SqlConnection con = new SqlConnection(constr))
            {
                string query = "INSERT INTO TableName VALUES (@Name, @ContentType, @Data)";
                using (SqlCommand cmd = new SqlCommand(query))
                {
                    cmd.Connection = con;
                    cmd.Parameters.AddWithValue("@Name", code);
                    cmd.Parameters.AddWithValue("@ContentType", "image/png");
                    cmd.Parameters.AddWithValue("@Data", byteImage);
                    con.Open();
                    cmd.ExecuteNonQuery();
                    con.Close();
                }
            }
        }
    }
}