I solved the problem by adding check in your script :
Add l.id = "HeaderGrid"; And check the existence of page
(function (a) {
a.fn.Scrollable = function (b) {
var c = {
ScrollHeight: 300
Width: 0
IsInUpdatePanel: false
} ;
var b = a.extend (c, b);
return this.each (function () {
var c = a (this). get ( 0);
var d = c.id;
MakeScrollable (c, b);
if (b.IsInUpdatePanel) {
var e = Sys.WebForms.PageRequestManager.getInstance ();
if (e! = null) {
e.add_endRequest (function (c, e) {
if($("div#HeaderGrid").length == 0){
MakeScrollable (a ("#" + d). Get ( 0 ), b)
}
} )
}
}
} )
}
}) (jQuery);
Your jquery plugin not working with multiple update panels :)