Pass (Send) multiple FileUpload controls to Generic Handler using jQuery AJAX in ASP.Net

Hui SajidHussa,

Refer below sample.

HTML

<script type="text/javascript" src="https://ajax.googleapis.com/ajax/libs/jquery/1.8.3/jquery.min.js"></script>
<script type="text/javascript">
    $(function () {
        $("#btnUpload").on("click", function () {
            var formData = new FormData();
            if ($('#File1')[0].files[0] != null) {
                formData.append($('#File1')[0].files[0].name, $('#File1')[0].files[0]);
            }
            if ($('#File2')[0].files[0] != null) {
                formData.append($('#File2')[0].files[0].name, $('#File2')[0].files[0]);
            }
            if ($('#File3')[0].files[0] != null) {
                formData.append($('#File3')[0].files[0].name, $('#File3')[0].files[0]);
            }
            if ($('#File4')[0].files[0] != null) {
                formData.append($('#File4')[0].files[0].name, $('#File4')[0].files[0]);
            }
            $.ajax({
                url: 'Handler.ashx',
                type: 'POST',
                data: formData,
                cache: false,
                contentType: false,
                processData: false,
                success: function (result) {
                }, error: function (r) {
                    alert(r.d);
                }
            });
        });
    });
</script>
<input type="file" id="File1" /><br />
<input type="file" id="File2" /><br />
<input type="file" id="File3" /><br />
<input type="file" id="File4" /><br />
<input type="button" id="btnUpload" value="Upload" />

Handler

C#

<%@ WebHandler Language="C#" Class="Handler" %>

using System;
using System.Web;
using System.IO;

public class Handler : IHttpHandler
{
    public void ProcessRequest(HttpContext context)
    {
        if (context.Request.Files.Count > 0)
        {
            for (int i = 0; i < context.Request.Files.Count; i++)
            {
                HttpPostedFile postedFile = context.Request.Files[i];
                string folderPath = context.Server.MapPath("~/Uploads/");
                string fileName = Path.GetFileName(postedFile.FileName);
                postedFile.SaveAs(folderPath + fileName);
            }
        }
    }

    public bool IsReusable
    {
        get
        {
            return false;
        }
    }
}

VB.Net

<%@ WebHandler Language="VB" Class="Handler" %>

Imports System
Imports System.Web
Imports System.IO

Public Class Handler : Implements IHttpHandler

    Public Sub ProcessRequest(ByVal context As HttpContext) Implements IHttpHandler.ProcessRequest
        If context.Request.Files.Count > 0 Then
            For i As Integer = 0 To context.Request.Files.Count - 1
                Dim postedFile As HttpPostedFile = context.Request.Files(i)
                Dim folderPath As String = context.Server.MapPath("~/Uploads/")
                Dim fileName As String = Path.GetFileName(postedFile.FileName)
                postedFile.SaveAs(folderPath & fileName)
            Next
        End If
    End Sub

    Public ReadOnly Property IsReusable() As Boolean Implements IHttpHandler.IsReusable
        Get
            Return False
        End Get
    End Property

End Class