Generate Excel file with ReadOnly column using Response.Write in ASP.Net

Is it possible to generate excel with some cloumns readyonly using respone object?

I am using following code to generate excel. Its working fine but want set some column read only.

string style = @"<style> .textmode { mso-number-format:\@;border : 1px Solid Black;} </style>";
Response.Write(style);
Response.Output.Write(sw.ToString());
Response.Flush();
Response.End();