Amol111 says:
<script type="text/javascript">
         function KeyPress(e) {
             var evtobj = window.event ? event : e
             
             if (evtobj.keyCode == 65 && evtobj.altKey)
             {
 
                 alert(" Alter Alt +A Press");
             }
             
             if (evtobj.keyCode == 46 && evtobj.shiftKey) {
                 alert("Shift + Delete Pressed");
             }
 
         }
         document.onkeydown = KeyPress;
     </script>
 replace above code with below
<script type="text/javascript">
    function KeyPress(e) {
        var evtobj = window.event ? event : e
        //Do action on Alt + A
        if (evtobj.keyCode == 65 && evtobj.altKey)// its checks the alt+A Is press
        {
            __doPostBack("<%= btnSaveBill.UniqueID %>", "");
        }
        //Do action on SHIFT + DELEETE
        if (evtobj.keyCode == 46 && evtobj.shiftKey) {
            alert("Shift + Delete Pressed");
        }
    }
    document.onkeydown = KeyPress;       
</script>