HI Waghmare,

Refer below sample.

HTML

<asp:FileUpload ID="fuUpload" runat="server" />
<asp:Button Text="Upload" runat="server" OnClick="OnUpload" />

Namespaces

C#

using System.Configuration;
using System.Data.SqlClient;
using System.IO;
using System.Net;

VB.Net

Imports System.Configuration
Imports System.Data.SqlClient
Imports System.IO
Imports System.Net

Code

C#

protected void OnUpload(object sender, EventArgs e)
{
    string serverName = "//yourserver.com/";
    string folder = "Uploads/";
    string fileName = Path.GetFileName(fuUpload.FileName);

    // Upload to current server.
    fuUpload.PostedFile.SaveAs(Server.MapPath("~/" + folder + fileName));
    // Save path in database.
    using (SqlConnection conn = new SqlConnection(ConfigurationManager.ConnectionStrings["constr"].ConnectionString))
    {
        string sql = "INSERT INTO Files VALUES(@Name, @Path)";
        using (SqlCommand cmd = new SqlCommand(sql, conn))
        {
            cmd.Parameters.AddWithValue("@Name", fileName);
            cmd.Parameters.AddWithValue("@Path", folder + fileName);
            conn.Open();
            cmd.ExecuteNonQuery();
            conn.Close();
        }
    }

    // Upload to Hosted Server.
    WebClient webClient = new WebClient();
    webClient.Credentials = new NetworkCredential("UserName", "Password"); ;
    Uri uri = new Uri(serverName + folder + fileName);
    webClient.UploadFile(uri, "POST", fileName);
}

VB.Net

Protected Sub OnUpload(ByVal sender As Object, ByVal e As EventArgs)
    Dim serverName As String = "//yourserver.com/"
    Dim folder As String = "Uploads/"
    Dim fileName As String = Path.GetFileName(fuUpload.FileName)

    ' Upload to current server.
    fuUpload.PostedFile.SaveAs(Server.MapPath("~/" & folder & fileName))
    ' Save path in database.
    Using conn As SqlConnection = New SqlConnection(ConfigurationManager.ConnectionStrings("constr").ConnectionString)
        Dim sql As String = "INSERT INTO Files VALUES(@Name, @Path)"
        Using cmd As SqlCommand = New SqlCommand(sql, conn)
            cmd.Parameters.AddWithValue("@Name", fileName)
            cmd.Parameters.AddWithValue("@Path", folder & fileName)
            conn.Open()
            cmd.ExecuteNonQuery()
            conn.Close()
        End Using
    End Using

    ' Upload to Hosted Server.
    Dim webClient As WebClient = New WebClient()
    webClient.Credentials = New NetworkCredential("UserName", "Password")
    Dim uri As Uri = New Uri(serverName & folder & fileName)
    webClient.UploadFile(uri, "POST", fileName)
End Sub