You can set the ToolTip property
<cc1:TabContainer ID="TabContainer1" runat="server" ActiveTabIndex="0">
<cc1:TabPanel ID="TabPanel1" runat="server" HeaderText="TabPanel1" ToolTip = "Tooltip_TabPanel1">
<ContentTemplate>
Tab 1
</ContentTemplate>
</cc1:TabPanel>
<cc1:TabPanel ID="TabPanel2" runat="server" HeaderText="TabPanel2" ToolTip = "Tooltip_TabPanel2">
<ContentTemplate>
Tab 2
</ContentTemplate>
</cc1:TabPanel>
<cc1:TabPanel ID="TabPanel3" runat="server" HeaderText="TabPanel3" ToolTip = "Tooltip_TabPanel3">
<ContentTemplate>
Tab 3
</ContentTemplate>
</cc1:TabPanel>
</cc1:TabContainer>