Try this
<asp:TextBox ID="TextBox1" runat="server"></asp:TextBox>
<asp:TextBox ID="TextBox2"
runat="server" ontextchanged="TextBox2_TextChanged" AutoPostBack="true"></asp:TextBox>
<asp:TextBox ID="TextBox3" runat="server"></asp:TextBox>
protected void TextBox2_TextChanged(object sender, EventArgs e) {
TextBox3.Text = Convert.ToString(Convert.ToInt32(TextBox1.Text) * Convert.ToInt32(TextBox2.Text));
}