Failed to load resource: the server responded with a status of 500 (Internal Server Error) sys is n

http://www.example.com:83/js.axd?path=%2fWebResource.axd%3fd%3......

-> Failed to load resource: the server responded with a status of 500 (Internal Server Error)

-> Uncaught Error: ASP.NET Ajax client-side framework failed to load.

-> Uncaught ReferenceError: Type is not defined

-> Uncaught ReferenceError: Sys is not defined

We have just migrate our application from server 2003 to server 2012 R2. That's works server 2003 but not working on server 2012 R2.

We have added following setting in web.config:

 </system.web>
    <httpHandlers>
            <add verb="*" path="*js.axd" type="ScriptCompressorHandler" />
        </httpHandlers>
        <httpModules>
            <add type="ScriptCompressorModule" name="ScriptCompressorModule" />
        </httpModules>
    </system.web>