Execute Multiple SqlCommand queries within a singe SqlConnection in ASP.Net

Hi. On my button click event, I have 3 tasks to do: 1) to update one of my sql database tables & 2) to insert variables in another sql database tables. My questions are:

a) Can I execute multiple sqlCommands within one sqlConnection Open() and Close() block?

b) What is the best method to achieve this?  - I tried separate connections and commands and also using block method my in both the cases, my first command works and other one doesn’t.

Please advise. Thanks in advance. Sat