Disable ASP.Net GridView cell in Edit mode based on condition using C# and VB.Net

Hi nicholas.tan,

Refer below code.

HTML

<asp:GridView ID="GridView1" runat="server" AutoGenerateColumns="false">
    <Columns>
        <asp:BoundField DataField="Id" HeaderText="Id" />
        <asp:BoundField DataField="Name" HeaderText="Name" />
        <asp:BoundField DataField="Country" HeaderText="Country" />
    </Columns>
</asp:GridView>

Code

C#

protected void Page_Load(object sender, EventArgs e)
{
    if (!this.IsPostBack)
    {
        DataTable dt = new DataTable();
        dt.Columns.AddRange(new DataColumn[3] {
            new DataColumn("Id"),
            new DataColumn("Name"),
            new DataColumn("Country")
        });
        dt.Rows.Add(1, "John Hammond", "United States");
        dt.Rows.Add(2, "Mudassar Khan", "India");
        dt.Rows.Add(3, "Suzanne Mathews", "France");
        dt.Rows.Add(4, "Robert Schidner", "Russia");
        GridView1.DataSource = dt;
        GridView1.DataBind();
        for (int column = 0; column < GridView1.Columns.Count; column++)
        {
            bool isEmpty = false;
            for (int row = 0; row < GridView1.Rows.Count; row++)
            {
                string value = GridView1.Rows[row].Cells[column].Text.Trim();
                if (string.IsNullOrEmpty(value) || value == "&nbsp;")
                {
                    isEmpty = true;
                }
                else
                {
                    break;
                }
            }
            if (isEmpty)
            {
                for (int row1 = 0; row1 < GridView1.Rows.Count; row1++)
                {
                    GridView1.Rows[row1].Cells[column].Enabled = false;
                }
            }
        }
    }
}

VB.Net

Protected Sub Page_Load(ByVal sender As Object, ByVal e As EventArgs) Handles Me.Load
    If Not Me.IsPostBack Then
        Dim dt As DataTable = New DataTable()
        dt.Columns.AddRange(New DataColumn(2) {
                            New DataColumn("Id"),
                            New DataColumn("Name"),
                            New DataColumn("Country")})
        dt.Rows.Add(1, "John Hammond", "United States")
        dt.Rows.Add(2, "Mudassar Khan", "India")
        dt.Rows.Add(3, "Suzanne Mathews", "France")
        dt.Rows.Add(4, "Robert Schidner", "Russia")
        GridView1.DataSource = dt
        GridView1.DataBind()
        For column As Integer = 0 To GridView1.Columns.Count - 1
            Dim isEmpty As Boolean = False
            For row As Integer = 0 To GridView1.Rows.Count - 1
                Dim value As String = GridView1.Rows(row).Cells(column).Text.Trim()
                If String.IsNullOrEmpty(value) OrElse value = " " Then
                    isEmpty = True
                Else
                    Exit For
                End If
            Next
            If isEmpty Then
                For row1 As Integer = 0 To GridView1.Rows.Count - 1
                    GridView1.Rows(row1).Cells(column).Enabled = False
                Next
            End If
        Next
    End If
End Sub